DPP-4 inhibitors [37], which elevate incretin hormone levels to maintain glucose homeostasis, have yielded mixed findings regarding their association with intestinal obstruction: a smaller study of 40,615 patients indicated a potential risk [15], while a larger cohort study of 190,321 patients across three countries found no increased risk [16]
A clinical review published in 2025 proposed that GLP-1 agonist modulation via increased serotonergic activity at the 5-HT2C receptor may result in diminished sexual desire
Harada N, Inagaki N
Supplementing with tyrosine is another option
The gut microbiota significantly contributes to the progression of numerous illnesses and exhibits distinct alterations in response to different conditions
Y., Elbrecht, A., Dashkevicz, M., Van der Ploeg, L